See Also: tropine tropate(medicine)
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medicine man(encyclopedia)

Arginase (medicine) and tropine tropate (medicine)


Arginase (medicine)


arginase
<enzyme> A ureahydrolase that catalyses the hydrolysis of arginine and canavanine to yield l-ornithine and urea.

Chemical name: L-Arginine amidinohydrolase

Registry number: EC 3.5.3.1


tropine tropate (medicine)


tropine tropate -->
atropine
<drug> A toxic alkaloid extracted from belladonna and Other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms.

Pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and AV conduction.

Uses: Treat bradycardia, asystole, and AV blockDose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects Atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 mL sterile water or normal saline.

Potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause deliriumNote: The denervated heart will not respond to atropine.