See Also: buthionine sulfoximine(medicine)
methionine sulfoximine(medicine)
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buthionine sulfoximine (medicine)


buthionine sulfoximine
<chemical> A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation.

Pharmacological action: antimetabolites, antimetabolites, antineoplastic, enzyme inhibitors, radiation-protective agents, radiation-sensitizing agents.

Chemical name: Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-