See Also: chimeric-2fhumanised antibody(medicine)
chimeric antibody(medicine)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
Chimeric(medicine)
chimeric DNA(medicine)
chimeric molecule(medicine)
chimeric antibodies(medicine)
chimeric proteins(medicine)
Medicine Lodge Memorial Hospital- Medicine Lodge(health)
Orthomolecular medicine (orthomolecular nutritional medicine, orthomolecular therapy)(health)

chimeric-2fhumanised antibody (medicine)


chimeric/humanised antibody
<immunology> Genetically engineered combination of a human and mouse antibody. Because a monoclonal antibody is always made with mice cells, it causes an immune response when injected into humans.

By replacing the constant regions of a mouse antibody with those of a human antibody, an antibody that binds to an antigen like the original monoclonal antibody, but which is recognised by the human immune system like a human protein, can be manufactured. Alternatively, only those amino acids directly involved in antigen binding are transferred from the mouse antibody into the framework of the human antibody, with a similar result.