See Also: Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
calmodulin-dependent protein kinase IV kinase(medicine)
AMP-activated protein kinase kinase(medicine)
MAPKAP kinase-2 reactivating kinase(medicine)
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Medicine Lodge Memorial Hospital- Medicine Lodge(health)
Orthomolecular medicine (orthomolecular nutritional medicine, orthomolecular therapy)(health)
protein kinase B kinase(medicine)
leukocyte tyrosine kinase receptor tyrosine kinase(medicine)
medicine(dictionary)

kinase II (medicine)


kinase II -->
peptidyl-dipeptidase A
<enzyme> A hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine.

An important step in the metabolism of certain vasopressor agents.

It is a chloride-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline. It may also have endopeptidase activity on some substrates.

Registry number: EC 3.4.15.1

Synonym: carboxycathepsin, dipeptidyl carboxypeptidase, kinase II, peptidase P.