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monoamine oxidase inhibitor (medicine)


monoamine oxidase inhibitor
<pharmacology> A drug that interferes with the action of monoamine oxidase, slowing the breakdown of certain neurotransmitters. Used in the treatment of depression.

Monoamine oxidase inhibitors are a group of antidepressant drugs that prevent the activity of the enzyme monoamine oxidase in the central nervous system (brain) thus affecting mood. The use of these medications is often restricted due to their severe side effects and drug (and food) interactions.

Examples include isocarboxazid, pargyline, selegiline, furazolidone and phenelzine.

Acronym: MAOI