See Also: peptidyl-dipeptidase A(medicine)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
peptidyl-Asp metalloendopeptidase(medicine)
peptidyl-Lys metalloendopeptidase(medicine)
peptidyl leukotrienes(medicine)
peptidyl prolyl cis trans isomerase(medicine)
dipeptidase(medicine)
glycylprolyl dipeptidase(medicine)
leukotriene D4 dipeptidase(medicine)
proline dipeptidase(medicine)

peptidyl-dipeptidase A (medicine)


peptidyl-dipeptidase A
<enzyme> A hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine.

An important step in the metabolism of certain vasopressor agents.

It is a chloride-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline. It may also have endopeptidase activity on some substrates.

Registry number: EC 3.4.15.1

Synonym: carboxycathepsin, dipeptidyl carboxypeptidase, kinase II, peptidase P.