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phosphoinositide (medicine) and warsle (iou)


phosphoinositide (medicine)


phosphoinositide -->
phosphatidylinositol
<biochemistry> A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.

It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid.

The 4 phosphate (PIP) and 4, 5 bisphosphate Derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles).

Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers.

Synonym: phosphoinositide.


warsle (iou)



warsle verb & noun. Scot. & north. LME.
[Metath. alt. of WRESTLE verb, noun.]
A. verb.
a. verb intrans. Wrestle (with), struggle. LME.
b. verb trans. Wrestle with (an adversary). L18.
verb intrans. Move with difficulty; struggle through, over, etc. (lit. & fig.). L15.
b. verb trans. Get (a thing) on, out, up with a struggle. L18.
b. noun. A struggle, a tussle (lit. & fig.); a wrestling bout. L18.