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propranolol (medicine)


propranolol
<drug> Potent adrenergic antagonist acting at beta-1 and beta-2 adrenergic receptors.

Pharmacologic action: Non-selective beta blockade (beta-1 and beta-2), reduces heart rate, myocardial contractility, and blood pressure, but also reduces myocardial oxygen demand.

Uses: Atrial and ventricular tachyarrhythmias caused by catecholamines; hypertension, myocardial ischemia; hyperthyroidism, hypertrophic cardiomyopathy.

Dose: 0.25 - 0.5 mg test dose, then 1 mg IV q min to desired effect Total dose should not exceed 0.1 mg/kg.

Onset: 2 min Duration: 1 - 6 hr.

Potential complications: Hypotension, bradycardia, worsened AV block, congestive heart failure and bronchospasm are unusual at low doses.

Chemical name: 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride.