See Also: Milstein, Cesar(encyclopedia)
Cesar's(tourism)
CESAR(tourism)
Cesar hotels(tourism)
Roux, Cesar(medicine)
Cesar (as used in expressions)(encyclopedia)
Chavez, Cesar(dictionary)
Beguez Cesar, Antonio(medicine)
La Harpe, Frederic-Cesar de(encyclopedia)
Franck, Cesar(-Auguste)(encyclopedia)

Milstein, Cesar (sh)




born Oct. 8, 1927, Bahia Blanca, Arg.
died March 24, 2002, Cambridge, Cambridgeshire, Eng.

Argentinian-born British immunologist.

In 1975 Milstein and Georges K?hler (1946-95) fused short-lived, highly specific lymphocytes with the cells of a myeloma, a type of tumour that can reproduce indefinitely. The hybrid cells, like lymphocytes, secreted antibody to a single antigen and, like myeloma cells, perpetuated themselves. This enabled production of large quantities of pure antibodies against single antigenic characteristics (monoclonal antibodies). Milstein, K?hler, and Niels K. Jerne (1911-94) shared the Nobel Prize in 1984.