See Also: Amyotrophic lateral sclerosis 7(health)
Amyotrophic lateral sclerosis 2(health)
Amyotrophic lateral sclerosis 3(health)
Amyotrophic lateral sclerosis 1(health)
Amyotrophic lateral sclerosis(medicine)
Amyotrophic lateral sclerosis 4(health)
Amyotrophic lateral sclerosis 5(health)
Amyotrophic lateral sclerosis 8(health)
Amyotrophic lateral sclerosis (ALS)(health)
Amyotrophic lateral sclerosis 6(health)

amyotrophic lateral sclerosis (ALS) (sh) and culmen (iou)


amyotrophic lateral sclerosis (ALS) (sh)




or Lou Gehrig disease

Degenerative nervous-system disorder causing muscle wasting and paralysis.

The disease usually occurs after age 40, more often in men. Most victims die within two to five years from respiratory muscle atrophy. ALS affects motor neurons; the muscles they control become weak and atrophied, with debility usually beginning in the hands and creeping slowly up to the shoulders. The lower limbs become weak and spastic. Variants include progressive muscular atrophy and progressive bulbar palsy. In 1993 the defective gene that accounts for 5-10% of cases was discovered; it produces an ineffective version of an enzyme that neutralizes free radicals, which destroy motor neurons.


culmen (iou)



culmen noun. M17.
[Latin, contr. of columen top, summit, etc.]
The top, the summit; fig. the acme, the culminating point. M17.
The upper ridge of a bird's bill. M19.
Anatomy. An anterior part of the vermis of the cerebellum bounded by deep fissures. L19.